@charset "utf-8";
:root {
  --yellow-color: #F1C400;
  --dark-blue-color: #001E62;
  --gray-color: #F6F6F6;
  --vermilion-color: #C63527;
}

*, article, aside, canvas, details, figcaption, figure,
header, footer, hgroup, nav, section, summary, main {
  margin: 0;
  padding: 0;
}
html,body{
  font-size: 62.5%;
}
html {
  height:100%;
}

/*----------------------------------------
	Global Styles
----------------------------------------*/
body {
  color: #333333;
  font-family: "Roboto", "Arial", "Droid Sans", "游ゴシック", "Yu Gothic", "ヒラギノ角ゴ ProN W3", "Hiragino Kaku Gothic ProN", sans-serif;
  font-optical-sizing: auto;
  font-weight: normal;
  font-style: normal;
  font-size: clamp(1.4rem,1.8vw,1.6rem);
  line-height: 1.875;
  background: #FFFFFF;
  min-height: 100vh;
  /*overflow-wrap: anywhere; /* 収まらない場合に折り返す */
  /*word-break: normal; /* 単語の分割はデフォルトに依存 */
  /*line-break: strict; /* 禁則処理を厳格に適用 */
}

/*-----------------------------------------
  Reset or Normalize
-----------------------------------------*/
/* 画像全体 */
img {
  border: 0;
  vertical-align: top;
  max-width: 100%;
  height: auto;
}

/* 見出し */
h1, h2, h3, h4, h5, h6 {
  font-size: 100%;
  font-weight: normal;
}

/* リスト */
ol, ul, li {
  list-style-image: none;
  list-style-position: outside;
  list-style-type: none;
}

/* テーブル */
table {
  border-collapse: collapse;
}

article, aside, canvas, details, figcaption, figure, footer,
header, hgroup, main, menu, nav, picture, section, summary {
  display: block;
}

/* サブページ大見出し */
main h3 {
  background: #F7F7F7;
  border-left: 5px solid var(--yellow-color);
  line-height: 1.3;
  font-size: clamp(18px,2.34vw,24px);
  font-weight: bold;
  min-height: clamp(50px,6.5vw,70px);
  padding: 1rem 2rem 1rem 3rem;
  margin: clamp(16px,2.08vw,30px) auto;
  box-sizing: border-box;
  display: flex;
  align-items: center;
}
main h3.multiple_lines {
  padding: 1rem 2rem 1rem 5rem;
  text-indent: -2.5rem;
  /* text-indent: -2rem; */
}
main section:first-of-type h3 {
  margin-top: 0;
}

/* 一番最初にくる時はアキなしにする場合はここに書き足す */
main h4:first-child, main h5:first-child, main p:first-child, main table tr td p:first-child {
  margin-top: 0;
}

/* 組み合わせでアキなしする場合はここに書き足す */
main h3 + h4, main h4 + h5, main h3 + p ,main h4 + p, main h5 + p {
  margin-top:0;
}

/* サブページ中見出し  */
main h4 {
  margin-top: 1.5em;
  margin-bottom: 1em;
  font-size: 105%;
  font-weight: bold;
  position: relative;
}

/* サブページ小見出し  */
main h5 {
  margin: 1em 0 0.5em 0;
  padding:0.2em;
  font-weight: bold;
  border-bottom: 1px dotted #666666;
}

/* サブページ段落 */
main p {
  margin-top: 1em;
}
main p.zero {
  margin-top: 0;
}
main p.han {
  margin-top: 0.5em;
}

/* サブページリスト */
main ul {
  margin-left: 1em;
}
main ul li {
  list-style: disc;
}
main ul.half li {
  margin-bottom: 0.5em;
}
main ol {
  margin-left: 1.5em;
}
main ol li {
  list-style: decimal;
}

main h4.indent_minus1 {
  text-indent: -1rem;
}

/*----------------------------------------
	Header
----------------------------------------*/
.header .container {
  padding: 1.5rem;
  line-height: 1.5;
}
.header h1 a {
  font-size: clamp(18px,2.6vw,48px);
  font-weight: 900;
  color: var(--dark-blue-color);
  padding: 0 0 1rem;
  display: flex;
  text-decoration: none;
}
.header h1 a:hover {
  opacity: 0.6;
}
.header .subTitle {
  font-size: clamp(12px,1.5625vw,18px);
  text-align: left;
  font-weight: 600;
}
@media screen and (max-width: 480px),print {
  .header .subTitle {
    text-align: center;
  }

  /* 下記は削除しない */
}

/*----------------------------------------
	btn-lang
----------------------------------------*/
.nav_wrapper .btn_lang {
  display: flex;
  justify-content: center;
  align-items: center;
  width: clamp(40px,6.5vw,90px);
  height: clamp(40px,6.5vw,90px);
  border: 0;
  cursor: pointer;
  position: fixed;
  top: 15px;
  right:120px;
  right:clamp(60px,10vw,120px);
  z-index: 10;
  background: var(--dark-blue-color);
  border-radius: 50%;
  border: 2px solid var(--vermilion-color);
  background: var(--vermilion-color);
  box-sizing: border-box;
}
.nav_wrapper .btn_lang:hover {
  background: #FFFFFF;
}
.nav_wrapper .btn_lang a {
  text-decoration: none;
  font-size: 2rem;
  color: #FFFFFF;
  width: 100%; 
  height: 100%; 
  display: flex; justify-content: center; 
  align-items: center;
}
.nav_wrapper .btn_lang:hover a {
  color: var(--vermilion-color);
}

/*----------------------------------------
	hamburger
----------------------------------------*/
.hamburger {
  display: flex;
  justify-content: center;
  align-items: center;
  width: clamp(40px,6.5vw,90px);
  height: clamp(40px,6.5vw,90px);
  border: 0;
  cursor: pointer;
  position: fixed;
  top: 15px;
  right: 10px;
  z-index: 10;
  background: var(--dark-blue-color);
  border-radius: 50%;
}
.hamburger_line {
  position: relative;
  width: 25px;
  height: 3px;
  background: #FFFFFF;
}
.hamburger_line::before,
.hamburger_line::after {
  position: absolute;
  content: "";
  display: block;
  width: 25px;
  height: 3px;
  background: #FFFFFF;
  transition: 0.3s all;
}
.hamburger_line::before {
  top: -8px;
}
.hamburger_line::after {
  bottom: -8px;
}
/* 閉じる */
.hamburger.active .hamburger_line {
  background: transparent;
}
.hamburger.active .hamburger_line::before {
  top: 0;
  transform: rotate(45deg);
}
.hamburger.active .hamburger_line::after {
  bottom: 0;
  transform: rotate(-45deg);
}
.menu_text {
  display: none;
}

/*----------------------------------------
	header_gnav
----------------------------------------*/
.header_gnav {
  display: none;
  position: fixed;
  top: 0;
  left: 0;
  z-index: 4;
  width: 100%;
  height: 100svh;
  height: 100svh;
  background: #FFFFFF;
  font-size: 1.6rem;
  padding: 90px 0 60px;
  box-sizing: border-box;
  overflow-y: scroll;
}
.header_gnav > ul {
  display: flex;
  flex-direction: column;
}
.header_gnav > ul > li {
  border-top: 1px solid #CCCCCC;
}
.header_gnav > ul > li:last-of-type {
  border-bottom: 1px solid #CCCCCC;
}
.header_gnav > ul > li.has-child ul > li {
  border-top: 1px solid #CCCCCC;
  width: 100%;
  padding:0 1rem 0 4rem;
  box-sizing: border-box;
  background: #EDF1FA;
}
.header_gnav > ul > li a {
  padding: 0.5rem 0;
  color: var(--dark-blue-color);
}
.header_gnav > ul > li > a {
  display: flex;
  align-items: center;
  padding: 0 1rem 0 2rem;
  box-sizing: border-box;
  text-decoration: none;
  width: 100%;
  height: 6rem;
  font-weight: bold;
}
.header_gnav > ul > li.has-child ul a {
  display: flex;
  align-items: center;
  width: 100%;
  height: 6rem;
  font-weight: bold;
  font-size: 14px;
  text-decoration: none;
}
.header_gnav > ul > li.has-child > a {
  position: relative;
}
.header_gnav > ul > li.has-child > a::before {
  content: '';
  position: absolute;
  top: 0;
  bottom: 0;
  right: 2rem;
  width: 10px;
  height: 10px;
  margin: auto;
  border-top: 2px solid var(--dark-blue-color);
  border-right: 2px solid var(--dark-blue-color);
  transform-origin: center;
  transform:rotate(135deg);
  box-sizing: border-box;
  transition: 0.3s all;
}
.header_gnav > ul > li.has-child > a.active::before {
  transform:rotate(-45deg);
}
.header_gnav > ul > li.has-child ul {
  display: none;
}
.header_gnav > ul > li.has-child ul.active {
  display: block;
}

/*----------------------------------------
	gnav
----------------------------------------*/
nav.gnav {
  width: 100%;
  background: #FDF6DD;
  padding: 5rem 0 1rem;
  display: none;
}

/*----------------------------------------
	mainContents
----------------------------------------*/
section {
  max-width: 1400px;
  width: 100%;
  margin: auto;
}
.container {
  padding: 0 2rem;
  box-sizing: border-box;
}
section p {
  margin-top: 1.5rem;
  line-height: 1.6;
}
.page_single section {
  max-width: 1000px;
}


/*----------------------------------------
	Breadcrumb 
----------------------------------------*/
.breadcrumb {
  max-width: 1400px;
  width: 100%;
  margin: 2rem auto 4rem;
  padding: 0 6rem;
  box-sizing: border-box;
  display: none;
}
.breadcrumb ul {
  display: flex;
  flex-wrap: wrap;
  list-style: none;
  margin: 0;
  padding: 0;
  font-size: 1.4rem;
}
.breadcrumb li:not(:last-child)::after {
  display: inline-block;
  margin: 0 .25rem;
  content: ">";
}

/*----------------------------------------
  hero
----------------------------------------*/
section.hero {
  max-width: inherit;
  background: #FDF6DD;
  position: relative;
}
.hero .container {
  padding: 3rem 0;
  display: flex;
  flex-direction: column;
}
.hero,
.hero .title {
  font-family: "fot-tsukuardgothic-std", sans-serif;
  font-weight: 700;
  font-style: normal;
  /* font-size: clamp(16px,1.5vw,22px); */
  color: var(--dark-blue-color);
}
.hero .inner {
  padding: 0 2rem 2rem;
  font-size: clamp(1.8rem,2.3vw,3.4rem);
}
.hero .lead {
  /* font-size: clamp(24px,3.125vw,48px); */
  /* margin-bottom: 1rem; */
  /* text-align: center; */
  visibility: hidden;
  transform: translateY(10%);
  transform: translate3d(0);
  margin-top: 0;
}
.hero .title,
.hero .subTitle {
  padding: 0;
  margin-top: 0;
  /* margin-bottom: 2rem; */
  visibility: hidden;
  transform: translateY(10%);
  /* transform: translate3d(0); */
  /* text-indent: -2rem; */
}
.hero_images {
  max-width: 700px;
  width: 100%;
  margin: 0 auto;
  display: flex;
}
.img_left,.img_center,.img_right {
  visibility: hidden;
}
.img_left {
  position: relative;
  left: 4.285%;
  z-index: 1;
}
.img_right {
  position: relative;
  left: -4.285%;
  z-index: 1;
}
.img_center {
  z-index: 2;
}

/* 下層ページタイトル */
.page_single section {
  margin-bottom: 5rem;
}
section.page_title {
  max-width: inherit;
  width: 100%;
  padding: 0;
  margin-bottom: 3rem;
  background: #FDF6DD;
}
.page_title h2 {
  padding: 3rem 0;
  box-sizing: border-box;
  font-size: clamp(24px,3.125vw,36px);
  font-weight: 700;
  text-align: center;
  letter-spacing: 1px;
  color: var(--dark-blue-color);
  line-height: 1.4;
}
.page_nav {
  margin-bottom: 3rem;
}
.page_nav ul {
  display: flex;
  align-items: center;
  justify-content: center;
  flex-direction: row;
  gap: 3rem;
}
.page_nav ul li a {
  font-size: clamp(16px,2vw,24px);
  width: clamp(100px,13vw,160px);
  height: clamp(100px,13vw,160px);
  font-weight: bold;
  display: flex;
  align-items: center;
  justify-content: center;
  text-align: center;
  padding: 0.5rem;
  color: var(--dark-blue-color);
  border: 1px solid var(--dark-blue-color);
  border-radius: 50%;
  box-sizing: border-box;
  text-decoration: none;
  transition: 0.3s all;
  line-height: 1.2;
}
.page_nav ul li a:hover,
.page_nav ul li a.active {
  color: #FFFFFF;
  background: var(--dark-blue-color);
}
.visually_hidden {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}

/*----------------------------------------
バナー掲載
----------------------------------------*/
.banner .container {
  padding-top: 5rem;
  padding-bottom: 5rem;
}
.banner h2 {
  font-size: 0;
}
.banner a {
  display: block;
  transition: 0.3s all;
}
.banner .slider a:hover {
  opacity: 0.6;
}
.slick-slide { /* 右側に10pxの間隔を設定 */
  margin-right: 10px; 
  margin-left: 10px; 
}
.slick-slide img {
  border: 1px solid var(--dark-blue-color);
  box-sizing: border-box;
}
.slick-dots {
  bottom: -40px;
}
.slick-dots li button:before {
  font-size: 10px;
}
.slick-prev {
  left: 50px;
  z-index: 3;
}
.slick-next {
  right: 50px;
  z-index: 3;
}
.slick-prev:before, .slick-next:before {
  color: var(--dark-blue-color);
}
@media screen and (max-width: 480px),print {
  .slick-dots {
    bottom: -30px;
  }
  .slick-dots li button:before {
    font-size: 6px;
  }

  /* 下記は削除しない */
}

/*----------------------------------------
最新情報
----------------------------------------*/
.news {
  margin-top: 3rem;
}
.news .title {
  font-size: clamp(24px,3.125vw,48px);
  font-weight: bold;
  letter-spacing: 0.15rem;
  padding-bottom: 3rem;
  border-bottom: 1px solid #999999;
  text-align: center;
  color: var(--dark-blue-color);
}
.news .wrapper {
  display: flex;
  flex-direction: column;
}
.news .wrapper dl {
  font-size: clamp(14px,1.82vw,24px);
  width: 100%;
  min-height: 150px;
  margin: 0 auto 3rem;
  padding: 3rem 2rem 4rem;
  border-bottom: 1px solid #999999;
  box-sizing: border-box;
  overflow:auto;
  display: flex;
  flex-direction: column;
}
.news .wrapper dt {
  font-weight: bold;
  padding-top: 2rem;
}
.news .news_button a {
  display:flex;
  align-items: center;
  justify-content: center;
  font-size: clamp(16px,2.08vw,24px);
  background: var(--yellow-color);
  color: #555555;
  max-width: 500px;
  width: 100%;
  height: 80px;
  box-sizing: border-box;
  border-radius: 40rem;
  margin:0 auto 7rem;
  position: relative;
  filter: drop-shadow(0px 0px 8px rgba(0,0,0,0.15));
  text-decoration: none;
  transition: 0.3s all;
}
.news .news_button a:hover {
  background: var(--dark-blue-color);
  color: #FFFFFF;
  filter: drop-shadow(0px 0px 10px rgba(0,0,0,0.3));
}
.news .news_button a::before {
  content: "";
  display: block;
  background: url(../images/icon_arrow_right.svg);
  width: 30px;
  height: 18px;
  position: absolute;
  top: calc(50% - 9px);
  right: 4rem;
  transition: 0.5s all;
}
.news .news_button a:hover::before {
  background: url(../images/icon_arrow_right_white.svg);
  right: 3rem;
}
.news .news_button {
  border-bottom: 1px solid #999999;
}

.news_list dl::-webkit-scrollbar ,
.news dl::-webkit-scrollbar {
  width: 12px; /* スクロールバーの幅 */
}
.news_list dl::-webkit-scrollbar-track,
.news dl::-webkit-scrollbar-track {
  background: #f1f1f1; /* トラックの背景色 */
  border-radius: 10px; /* 角を丸くする */
}
.news_list dl::-webkit-scrollbar-thumb,
.news dl::-webkit-scrollbar-thumb {
  background-color: var(--dark-blue-color); /* スライダーの色 */
  border-radius: 10px; /* 角を丸くする */
  border: 2px solid #fff; /* スライダーの周りに白いボーダーを追加 */
}
.news_list dl::-webkit-scrollbar-thumb:hover,
.news dl::-webkit-scrollbar-thumb:hover {
  background-color: var(--yellow-color); /* ホバー時のスライダーの色 */
}

/*----------------------------------------
お知らせ一覧 
----------------------------------------*/
.news_list dl {
  font-size: clamp(14px,1.82vw,24px);
  width: 100%;
  padding: 3rem 2rem 4rem;
  border-bottom: 1px solid #999999;
  box-sizing: border-box;
  display: flex;
  flex-direction: column;
}
.news_list dd {
  margin-bottom: 3rem;
}

/*----------------------------------------
footer
----------------------------------------*/
.footer {
  margin-top: 6rem;
  /* margin-top: 8rem; */
  font-size: 12px;
}
/* .news_list+.pagetop+footer>.footer {
  margin-top: initial;
} */
.footer .wrapper {
  text-align: center;
  font-weight: 500;
  margin-bottom: 1rem;
}
.footer h2 {
  font-size: clamp(20px,2.6vw,36px);
  /* font-weight: bold; */
  font-weight: 700;
  /* font-weight: 900; */
  color: var(--dark-blue-color);
  margin-bottom: 1.5rem;
  /* letter-spacing: 0.1rem; */
  line-height: 1.5;
}
.footer .subTitle {
  font-size: clamp(12px,1.625vw,18px);
  margin-bottom: 3rem;
  line-height: 1.5;
}
.footer h3 {
  font-size: clamp(14px,1.82vw,20px);
  font-weight: 600;
  color: var(--dark-blue-color);
  margin-bottom: 1rem;
  /* letter-spacing: 0.1rem; */
  line-height: 1.6;
}
.footer address {
  font-size: clamp(12px,1.625vw,16px);
  font-weight: 400;
  font-style: normal;
  line-height: 1.4;
}
footer {
  border-bottom: 2rem solid var(--dark-blue-color);
}
footer .copyright {
  font-size: 12px;
  padding: 0 1rem 2.5rem;
  box-sizing: border-box;
  text-align: center;
  line-height: 1.2;
  color: #999999;
}

/*----------------------------------------
先天性リポ...（LCAH）, 最新の研究, 目次付きページ
----------------------------------------*/
main {
  display: flex;
  flex-direction: column;
}
main.page .list_disc p {
  position: relative;
  padding-left: 2rem;
}
main.page .list_disc p:not(.no_disc)::before {
  content: "";
  display: block;
  position: absolute;
  top: 0.6rem;
  left: 0;
  background: #555555;
  width: 1.2rem;
  height: 1.2rem;
  border-radius: 50%;
}
main.page p.no_disc {
  padding-left: initial;
  margin-top: clamp(20px,2.6vw,20px);
  margin-bottom: clamp(50px,6.5vw,100px);
}
main.page p.no_disc.pl2 {
  padding-left: 2rem;
}
main.page p sup {
  font-size: 1.2rem;
  vertical-align: top;
}

/* 目次 */
#toc {
  padding: 0 2rem 2rem;
  box-sizing: border-box;
}
.toc_title {
  font-size: clamp(16px,2vw,24px);
  font-weight: bold;
  text-align: center;
  padding: 1rem;
  background: var(--yellow-color);
  color: var(--dark-blue-color);
  border: 1px slid var(--yellow-color);
  box-sizing: border-box;
  border-radius: 10px 10px 0 0;
}
/* カウンター */
#toc ol.inner {
  width: 100%;
  background: #FFFFFF;
  padding: 1rem 1rem 1rem 1.5rem;
  margin-left: 0;
  border: 1px solid var(--yellow-color);
  box-sizing: border-box;
  border-radius: 0 0 10px 10px;
  /* display: flex;
  flex-wrap: wrap; */
  box-sizing: border-box;
  counter-reset: listnum; /* カウンターをリセット */
  list-style: none;
  position: relative;
}
#toc ol.inner > li {
  position: relative;
  width: 50%;
  list-style: none;
  font-weight: bold;
}
#toc ol.inner li::before{
	counter-increment: listnum;
	content: counter(listnum) ".";
  position: absolute;
  top: 0.8rem;
  /* top: 1rem; */
  left: 0;
  font-size: clamp(14px,1.8vw,20px);
  color: var(--dark-blue-color);
}
#toc ol.inner > li a {
  display: block;
  padding: 1rem 2.5rem 1rem 1.5rem;
  box-sizing: border-box;
  font-size: clamp(14px,1.8vw,18px);
  color: var(--dark-blue-color);
  position: relative;
  text-decoration: none;
  line-height: 1.6;
  white-space: nowrap;
}
#toc ol.inner > li a.multiple_lines {
  font-size: clamp(14px, 1.8vw, 16px);
  line-height: 1.4;
  padding-top: 1.5rem;
}

/* 基礎研究：基礎研究：副腎皮質のマクロファージに関する研究 */
/* #toc.kiso ol.inner {
  width: 100%;
  display: flex;
  flex-direction: column;
}
#toc.kiso ol.inner > li {
  position: relative;
  width: 100%;
}
#toc.kiso ol.inner li::before{
	counter-increment: listnum;
	content: counter(listnum) ".";
  position: absolute;
  top: 1.1rem;
  left: 0;
  font-size: 14px;
  color: var(--dark-blue-color);
}
#toc.kiso ol.inner > li a.multiple_lines {
  font-size: 14px;
  line-height: 1.4;
  padding-top: 1.5rem;
} */
main.linsyo h3#section7 + p {
  padding-bottom: clamp(2rem,2.6vw,8rem);
}

/* 症例診断,臨床研究 */
main.linsyo p.link a,
main.iryo p.link a {
  font-size: clamp(16px,2.08vw,18px);
  text-decoration: underline;
  position: relative;
}
main.kanja p.link a:hover,
main.iryo p.link a:hover {
  text-decoration: none;
}
/* カウンター */
ol.counter {
  counter-reset: counter; /* カウンターをリセット */
  list-style: none; /* デフォルトのリストスタイルを削除 */
  padding-left: 1rem; /* 左の余白を削除 */
}
ol.counter li {
  list-style: none;
  position: relative;
  line-height: 1.875;
}
ol.counter li::before {
  counter-increment: counter;
  content: counter(counter) "）";
  display: block;
  position: absolute;
  right: 100%; /* 右揃え */
  margin-right: 0rem; /* 数字とテキストの間に少し余白 */
}


/*----------------------------------------
最新の研究
----------------------------------------*/

/*----------------------------------------
研究班の紹介
----------------------------------------*/
table.hyou_kenkyu {
  width: 100%;
  margin-bottom: 1em;
  font-size: clamp(14px,1.82vw,18px);
}
table.hyou_kenkyu td {
  border: 2px solid #FFFFFF;
  background: #F7F7F7;
  padding: 0.5em;
  vertical-align: top;
  text-align: left;
}
table.hyou_kenkyu th {
  border: 2px solid #FFFFFF;
  background: #EEEEEE;
  padding: 0.5rem 1rem;
  vertical-align: top;
  text-align: left;
  font-weight: normal;
  min-width: 10rem;
  white-space: nowrap;
}
main.hyou_kenkyu ol li {
  padding-bottom: 2rem;
}

/*----------------------------------------
 Pagetop
----------------------------------------*/
.pagetop {
  position: fixed;
  bottom: 30px;
  right: 10px;
  z-index: 4;
}
.pagetop a {
  display: block;
  background:var(--vermilion-color);
  border: 1px solid #FFFFFF;
  box-sizing: border-box;
  border-radius: 50%;
  width: 60px;
  height: 60px;
  position: relative;
  z-index: 2;
  opacity: 0.9;
  text-indent: 100%;
  overflow: hidden;
  white-space: nowrap;
}
.pagetop a::before {
  content: "";
  display: block;
  background: url(../images/icon_arrow_top.svg);
  width: 16px;
  height: 16px;
  position: absolute;
  top: calc(50% - 8px);
  left: calc(50% - 8px);
}
.pagetop a:hover {
  opacity: 0.6;
}

/*-----------------------------------------
  Links
-----------------------------------------*/
p.link a:link,
p.link a:visited {
  color: #333333;
  text-decoration: none;
}

p.link a:hover,
p.link a:active {
  color: #666666;
  text-decoration: underline;
}

a:link,
a:visited {
  color: #0066CC;
}

a:hover,
a:active {
  text-decoration: none;
}

a.external {
  background: url(../images/external.png) no-repeat right center;
  padding-right: 2rem;
  width: 24px;
  height: 24px;
}

/*-----------------------------------------
  Tables
-----------------------------------------*/
table.hyou_aaa {
  width: 100%;
  margin-bottom: 1em;
}

table.hyou_aaa td {
  border: 1px solid #666666;
  background-color: #FFFFFF;
  padding: 0.5em;
  vertical-align: top;
  text-align: left;
}

table.hyou_aaa th {
  border: 1px solid #666666;
  background-color: #F0FFEE;
  padding: 0.5em;
  vertical-align: top;
  text-align: left;
  font-weight: normal;
  width: 20%;
}

table.hyou_aaa tr {
  padding: 0.5em;
  vertical-align: top;
  text-align: left;
}

table.non {
  border: none;
}

table.non td {
  text-align: left;
  vertical-align: top;
}

table.non th {
  text-align: left;
  vertical-align: top;
  white-space: nowrap;
  font-weight: normal;
}

/*-----------------------------------------
  Text Styles
-----------------------------------------*/
.kome {
  padding-left: 1rem;
  text-indent: -1rem;
}

.mbm1 { margin-bottom: -1rem; }
.mb1 { margin-bottom: 1rem; }
.mb2 { margin-bottom: 2rem; }
.mb03 { margin-bottom: 0.3rem; }
.mb05 { margin-bottom: 0.5rem; }
.mb15 { margin-bottom: 1.5rem; }

.pl05 { padding-left: 0.5rem; }
.pl2 { padding-left: 2rem; }
.ml1 { margin-left: 1rem; }

.f85 { font-size: 85%; }
.f90 { font-size: 90%; }
.f95 { font-size: 95%; }
.f100 { font-size: 100%; }
.f105 { font-size: 105%; }
.f110 { font-size: 110%; }
.f115 { font-size: 115%; }
.f120 { font-size: 120%; }

.bold {
  font-style: normal;
  font-weight: bold !important;
}

.text_r {
  text-align: right;
}

.text_c {
  text-align: center;
}

/*-----------------------------------------
  Backgrounds
-----------------------------------------*/
.uchikeshi {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAABGdBTUEAAK/INwWK6QAAAANQTFRFAAAAp3o92gAAAApJREFUCB1jYAAAAAIAAc/INeUAAAAASUVORK5CYII=) 0 center repeat-x;
}

.uchikeshi.red {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAABGdBTUEAAK/INwWK6QAAAANQTFRF/wAAGeIJNwAAAApJREFUCB1jYAAAAAIAAc/INeUAAAAASUVORK5CYII=) 0 center repeat-x;
}

/*-----------------------------------------
  Colors
-----------------------------------------*/
.red { color: #FF0000; }
.blue { color: #1d2777; }

/*-----------------------------------------
  Underline
-----------------------------------------*/
.underline {
  text-decoration: underline;
}

/* テキスト両揃え */
.text_both {
  text-align: justify;
  text-justify: inter-ideograph;
}

/*-----------------------------------------
  ボタン
-----------------------------------------*/
.btn .inner {
  display: flex;
  justify-content: space-evenly;
  margin: 2rem auto;
  flex-wrap: wrap;
  gap: 1rem;
}
.btn .item a {
  flex: 1;
  display: block;
  padding: 20px;
  background: var(--dark-blue-color);
  border-radius: 8px;
  text-align: center;
  color: #FFFFFF;
  max-width: 350px;
  min-width: 300px;
  width: 100%;
  box-sizing: border-box;
  text-decoration: none;
  border: 1px solid var(--dark-blue-color);
  transition: 0.3s all;
  filter: drop-shadow(0px 0px 4px rgba(153, 153, 153, 0.2));
}
.btn .item a:hover {
  background: #FFFFFF;
  color: var(--dark-blue-color);
  filter: drop-shadow(0px 0px 4px rgba(0, 0, 0, 0.3));
}

/* spで表示 */
 .sp_only {
  display: inline-block;
}
/* spでは非表示 */
.pc_only {
  display: none;
}

  /*----------------------------------------
  pc用 768px
  ----------------------------------------*/
  @media screen and (min-width: 768px),print {
    /* スマホで非表示 */
    .sp_only {
      display: none;
    }
    /* pcでは表示 */
    .pc_only {
      display: inline-block;
    }

  /*----------------------------------------
    header
  ----------------------------------------*/
  .header .container {
    max-width: 1400px;
    width: 100%;
    padding: 1.5rem 4rem;
  }
  @media screen and (min-width: 1400px),print {
    .header .container {
      padding: 1.5rem 6rem 1.5rem 6vw;
    }
    /* 下記は削除しない */
  }
  @media screen and (min-width: 1900px),print {
    .header .container {
      padding: 1.5rem 6rem 1.5rem 12vw;
    }
    /* 下記は削除しない */
  }
   .header h1 a {
    white-space: nowrap;
    /* font-weight: 900; */
  }

  /*----------------------------------------
    hamburger
  ----------------------------------------*/
  .hamburger {
    right: 2rem;
  }
  
  .hamburger_line {
    width: 35px;
  }
  .hamburger_line::before,
  .hamburger_line::after {
    width: 35px;
  }

  .hamburger_line::before {
    top: -9px;
  }
  .hamburger_line::after {
    bottom: -9px;
  }
  @media screen and (min-width: 1000px),print {
    .menu_text {
      display: block;
      position: absolute;
      top: -2rem;
      left: 50%;
      transform: translate(-50%, -50%);
      color: #FFFFFF;
      font-size: 1.1rem;
      white-space: nowrap;
    }
    /* 下記は削除しない */
  }
  

  /*----------------------------------------
    header_gnav
  ----------------------------------------*/
  .header_gnav {
    left: auto;
    right: -2rem;
    min-width: 360px;
    width: 30%;
    height: 100dvh;
    background: rgb(0 30 98 / 0.95);
    padding: 110px 0 60px;
  }
  .header_gnav > ul {
    display: flex;
    flex-direction: column;
  }
  .header_gnav > ul > li {
    border-top: 1px solid #CCCCCC;
  }
  .header_gnav > ul > li:last-of-type {
    border-bottom: 1px solid #CCCCCC;
  }
  .header_gnav > ul > li.has-child ul > li {
    border-top: 1px solid #CCCCCC;
    width: 100%;
    padding:0 1rem 0 4rem;
    box-sizing: border-box;
    background: #EDF1FA;
  }
  .header_gnav > ul > li a {
    color: #FFFFFF;
  }
  .header_gnav > ul > li.has-child ul a {
    color: var(--dark-blue-color);
  }
  .header_gnav > ul > li.has-child ul a:hover,
  .header_gnav > ul > li > a:hover {
    text-decoration: underline;
  }
  .header_gnav > ul > li.has-child > a::before {
    right: 3.5rem;
    border-top: 2px solid #FFFFFF;
    border-right: 2px solid #FFFFFF;
  }

  /*----------------------------------------
    gnav
  ----------------------------------------*/
  nav.gnav {
    display: block;
    padding: 5rem 0 3rem;
  }
  nav.gnav > .container {
    width: 100%;
    
  }
  nav.gnav ul.gnav_list {
    max-width: 1400px;
    width: 98%;
    margin: 0 auto;
    background: #FFFFFF;
    display: flex;
    align-items: center;
    justify-content: space-around;
    border-radius: 50px;
    padding: 0 2rem;
    box-sizing: border-box;
    filter: drop-shadow(0px 0px 10px rgba(153, 153, 153, 0.1));
    position: relative;
    z-index: 3;
    line-height: 1.5;
  }
  nav.gnav ul.gnav_list > li > a {
    width: 100%;
    height: 9rem;
    display: flex;
    align-items: center;
    color: var(--dark-blue-color);
    padding: 0 1rem;
    box-sizing: border-box;
    text-decoration: none;
    font-size: clamp(12px,1.4vw,22px);
    font-weight: 500;
    position: relative;
    transition: 0.5s all;
  }
  nav.gnav ul.gnav_list > li > a::before {
    content: "";
    display: block;
    width: 16px;
    height: 16px;
    background: var(--yellow-color);
    position: absolute;
    top: calc(50% - 7px);
    left: -0.5rem;
    border-radius: 50%;
    transition: 0.3s all;
    visibility: hidden;
  }
  nav.gnav ul.gnav_list > li > a.active::before {
    content: "";
    display: block;
    width: 16px;
    height: 16px;
    background: var(--yellow-color);
    position: absolute;
    top: calc(50% - 7px);
    left: -1.2rem;
    border-radius: 50%;
    visibility: visible;
  }
  nav.gnav ul.gnav_list > li > a:hover::before {
    height: 16px;
    left: -1.2rem;
    visibility: visible;
  }
  nav.gnav .has-child {
    position: relative;
  }
  nav.gnav .has-child::after {
    content: '';
    position: absolute;
    top: -0.2rem;
    bottom: 0;
    right: -1rem;
    width: 10px;
    height: 10px;
    margin: auto;
    border-top: 3px solid var(--dark-blue-color);
    border-right: 3px solid var(--dark-blue-color);
    transform-origin: center;
    transform:rotate(135deg);
    box-sizing: border-box;
    transition: 0.5s all;
  }
  nav.gnav .has-child ul {
    background: #FFFFFF;
    position: absolute;
    top: 75px;
    left: 0;
    border-radius: 5px;
    filter: drop-shadow(0px 0px 5px rgba(0,0,0,0.1));
    transition: 0.3s ease-in-out;
    visibility: hidden; /*メニュー開く*/
    z-index: 6;
  }
  ::-webkit-full-page-media, :future, :root nav.gnav .has-child ul {
    transform: translate3d(0, 0, 0);
  }

  nav.gnav .has-child:hover ul {
    visibility: visible;
    top: 85px;
  }
  nav.gnav .has-child ul li a {
    display: flex;
    align-items: center;
    min-height: 50px;
    color: #333333;
    white-space: nowrap;
    padding: 1rem 2rem;
    box-sizing: border-box;
    font-size: 1.4rem;
    text-decoration: none;
    position: relative;
    letter-spacing: 0.5px;
  }
  nav.gnav .has-child ul li a:hover {
    color: var(--dark-blue-color);
    /* font-weight: bold; */
    text-shadow: 0 0 0.5px currentColor;
  }
  nav.gnav .has-child ul li a::before {
    color: var(--dark-blue-color);
    content: "";
    display: block;
    width: 0;
    height: 5px;
    background: var(--yellow-color);
    position: absolute;
    bottom: 0;
    left: auto;
    margin: auto;
    padding: 0;
    transition: 0.5s ease-in-out;
  }
  nav.gnav .has-child ul li a:hover::before {
    width: calc(100% - 40px);
    background: var(--yellow-color);
  }
  nav.gnav .has-child ul li:first-child a {
    border-bottom:1px solid #EEEEEE;
  }
  nav.gnav > ul > li.has-child > a {
    position: relative;
  }
  nav.gnav > ul > li.has-child > a::after {
    content: '';
    position: absolute;
    top: 40%;
    right: -1rem;
    width: 10px;
    height: 10px;
    margin: auto;
    border-top: 3px solid var(--dark-blue-color);
    border-right: 3px solid var(--dark-blue-color);
    transform-origin: center;
    transform:rotate(135deg);
    box-sizing: border-box;
    transition: 0.3s all;
  }
  ul.gnav_list [class^="has-"] > a {
    cursor: default;
  }

  /*----------------------------------------
    mainContents
  ----------------------------------------*/


  /*----------------------------------------
	Breadcrumb 
  ----------------------------------------*/
  .breadcrumb {
    display: block;
  }

  /*----------------------------------------
    hero
  ----------------------------------------*/
  .hero .container {
    padding: 5rem 0 10rem;
    flex-direction: row;
    align-items: center;
    max-width: 1400px;
    width: 100%;
    margin: 0 auto;
  }
  .hero .inner {
    padding: 0 0 0 5rem;
    width: 50%;
    /* font-size: 2.8rem; */
    margin-top: -8rem;
  }
  .hero .lead {
    /* margin-left: -0.5rem; */
    /* margin-bottom: 2rem; */
    text-align: left;
    /* margin-bottom: 0; */
    /* letter-spacing: 0.5rem; */
  }
  .hero .title,
  .hero .subTitle {
    /* padding: 0 2rem; */
    /* line-height: 1.6; */
    /* margin-top: 0; */
  }
  .hero_images {
    min-width: 450px;
  }
  /* スクロールダウン全体 */
  .scrolldown {
    position:absolute;
    top: 10vh;
    right: 3rem;
  }

  /* 下層ページタイトル */
  section.page_title {
    margin-bottom: 0;
  }
  .page_title h2 {
    padding: 1rem 1rem 6rem;
    line-height: 1.5;
  }

  /*----------------------------------------
  バナー掲載
  ----------------------------------------*/
  /* .banner ul {
    flex-direction: row;
    justify-content: center;
    gap: 2rem;
  } */

  /*----------------------------------------
  最新情報
  ----------------------------------------*/
  .news {
    margin-top: 6rem;
  }
  .news .title {
    /* width: 25%; */
    padding:3rem 0 4rem;
    /* border: none; */
  }
  .news .wrapper {
    /* flex-direction: row; */
    /* padding-top: 6rem; */
    /* border-top: 1px solid #999999; */
    box-sizing: border-box;
  }
  .news .wrapper dl {
    display: grid;
    grid-template-columns: auto 1fr;
    
    /* width: 75%; */
    /* display: flex;
    flex-direction: row;
    flex-wrap: wrap;
    align-items: flex-start; */
    /* align-items: center; */
    gap: 4rem 6rem;
  }
  .news .wrapper dt {
    padding-top: 0;
  }
  .news .wrapper dd {
    /* width: calc(85% - 6rem); */
  }
  .news .wrapper dd {
    margin-top: 0;
  }

  /*----------------------------------------
  お知らせ一覧 
  ----------------------------------------*/
  .news_list dl {
    display: grid;
    grid-template-columns: auto 1fr;
    gap: 4rem 6rem;
    margin: 3rem auto 3rem;
    padding: 4rem;
    border-top: 1px solid #999999;
    flex-direction: row;
    flex-wrap: wrap;
    /* gap: 4rem 0rem; */
    /* white-space: nowrap; */
    /* height: 500px; */
    overflow: auto;
  }
  .news_list dt {
    font-weight: bold;
    /* width: 20%; */
  }
  .news_list dd {
    /* width: 80%; */
    margin-bottom: initial;
  }

  /*----------------------------------------
  footer
  ----------------------------------------*/
  .footer h2 {
    /* font-weight: 900; */
  }

  /*----------------------------------------
  先天性リポ...（LCAH）, 最新の研究 目次付きページ
  ----------------------------------------*/
  main.page:not(.page_single) {
    flex-direction: row;
    justify-content: space-around;
    max-width: 1400px;
    width: 100%;
    margin: 0 auto;
  }
  
  /* 目次 */
  #toc {
    min-width: 340px;
    /* min-width: 320px; */
    padding: 0 2rem;
    position: sticky;
    top: 0;
    left: 0;
    height: 100%;
    overflow-y: auto;
    filter: drop-shadow(0px 0px 4px rgba(153, 153, 153, 0.2));
  }
  #toc ol.inner {
    flex-direction: column;
    padding: 3rem 2rem 4rem;
  }
  #toc ol.inner li::before{
    top: 1.5rem;
  }
  #toc ol.inner > li {
    width: 100%;
  }
  #toc ol.inner > li::after {
    content: "";
    display: block;
    width: 0;
    height: 3px;
    background: var(--yellow-color);
    position: absolute;
    bottom: 0;
    left: 0;
    transition: 0.3s all;
  }
  #toc ol.inner > li:hover::after {
    width: 100%;
  }
  #toc ol.inner > li a {
    display:flex;
    white-space:normal;
    padding: 2rem 2rem 1.5rem 2.5rem;
    border-bottom: 1px solid #DDDDDD;
    box-sizing: border-box;
    width: 100%;
    position: relative;
  }
  #toc ol.inner > li a::before {
    content: '';
    width: 22px;
    height: 22px;
    background: #FFEB86;
    border-radius: 50%;
    position: absolute;
    top: 4px;
    right: 0;
    bottom: 0;
    margin: auto;
  }
  #toc ol.inner > li a::after {
    content: '';
    width: 8px;
    height: 8px;
    border: 0;
    border-top: solid 2px var(--dark-blue-color);
    border-right: solid 2px var(--dark-blue-color);
    transform: rotate(135deg);
    position: absolute;
    top: 0;
    right: 6px;
    bottom: 0;
    margin: auto;
  }
  #toc ol.inner > li a.multiple_lines {
    padding-top: 2.5rem;
  }
  .page .container {
    padding: 0 20px 20px;
    width: 1000px;
  }

  /*----------------------------------------
  最新の研究
  ----------------------------------------*/


    

    /* 下記は削除しない */
  }